Journal of the Neurological Sciences issue 472 now available

Association between cognitive function and relaxation rates of the cerebral cortex

Published online: March 13, 2025

We aimed to elucidate the correlation between cognitive function and relaxation rates of the cerebral cortex in the early stages of cognitive decline.

Brain MRI was performed on 97 community-dwelling elderly participants aged 65–84 years. R1 (1/T1) and R2 (1/T2) maps were obtained with synthetic MRI (SyMRI). Cognitive function was evaluated using the Japanese version of the Montreal Cognitive Assessment (MoCA). Participants were categorized into mild cognitive impairment (n = 47) and healthy control (n = 50) groups. Voxel-based quantification (VBQ) and voxel-based morphometry (VBM) analyses were conducted using two-sample t-tests and multiple regression models, with age and sex as covariates.

Characterization of immune cell profiles in the blood of children and adults with tuberous sclerosis complex disease

Published online: March 13, 2025

Tuberous sclerosis (TSC) is characterised by the formation of benign tumours across various organs, particularly in the central nervous system (CNS), where they can lead to epilepsy and neurodevelopmental disorders. TSC results from variants in either TSC1 or TSC2 genes, leading to hyperactivation of the mTORC1 pathway, which plays a pivotal role in regulating cell growth and survival. While the influence of mTOR on immune function has been extensively investigated, our understanding of the composition of immune cells in TSC patients remains limited.

In utero exposure to synthetic sex hormones and their multigenerational impact on neurodevelopmental disorders: Endocrine disruptors as neuroendocrine disruptors

Published online: April 1, 2025

In this review, we have gathered the main works concerning the harmful effects of these synthetic sex hormones on human health and especially on neurodevelopment so that they are recognized, both for the purpose of teaching medical careers and prescribers and as a precaution for the general population and future generations.

Movement disorders in relapsing and progressive MS: A comprehensive prospective evaluation of a large real-life cohort

Published online: March 22, 2025

To evaluate the frequency, clinical characteristics, and anatomical generators of movement disorders in relapsing and progressive MS.

We conducted a prospective study of adult MS patients from 2016 to 2022 at a neuroimmunology clinic. Patients were evaluated for demyelination-related movement disorders via a survey and focused examination. We classified movement disorders based on phenomenology and identified anatomic correlates according to lesion locations and relation to relapses. Findings were compared between relapsing and progressive MS.